POSSIBLE MECHANISM OF ADVERSE REACTION FOLLOWING LEVODOPA PLUS BENSERAZIDE TREATMENT
نویسندگان
چکیده
منابع مشابه
Betaine protects cerebellum from oxidative stress following levodopa and benserazide administration in rats
Objective(s): The aim of the present study was to evaluate antioxidant and methyl donor effects of betaine in cerebellum following levodopa and benserazide administration in rats. Materials and Methods: Sprague-Dawley male rats were treated with levodopa (LD), betaine (Bet), levodopa plus betaine (LD/Bet), levodopa plus benserazide (LD/Ben), levodopa plus betaine-benserazide (LD/Bet-Ben), and t...
متن کاملBetaine protects cerebellum from oxidative stress following levodopa and benserazide administration in rats
OBJECTIVES The aim of the present study was to evaluate antioxidant and methyl donor effects of betaine in cerebellum following levodopa and benserazide administration in rats. MATERIALS AND METHODS Sprague-Dawley male rats were treated with levodopa (LD), betaine (Bet), levodopa plus betaine (LD/Bet), levodopa plus benserazide (LD/Ben), levodopa plus betaine-benserazide (LD/Bet-Ben), and the...
متن کاملControlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats
BACKGROUND Levodopa remains the most effective drug in the treatment of Parkinson's disease. However, long-term administration of levodopa induces motor complications, such as levodopa-induced dyskinesia. The mechanisms underlying levodopa-induced dyskinesia are not fully understood. METHODS In this study, we prepared levodopa methyl ester (LDME)/benserazide-loaded nanoparticles, which can re...
متن کاملاثرات حفاظت کبدی بتائین در مقابل استرس اکسیداتیو ناشی از لوودوپا و بنسرازید در موش‌های صحرایی
Introduction: Betaine has been demonstrated to have methyl donor and antioxidant properties in our previous reports. Thus, the aim of the present study was to determine plasma homocysteine concentration and evaluate antioxidant activity of betaine following levodopa and benserazide administration, which routinely are used in treatment of Parkinson’s disease in liver of rats. Methods: Sprague–...
متن کاملLevodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats
BACKGROUND Levodopa is the gold standard in the treatment of Parkinson's disease (PD). However, long-term levodopa replacement therapy is accompanied by abnormal involuntary movements (AIMs), known as levodopa-induced dyskinesia (LID). Until now, the precise mechanisms of LID were only partially understood. Previous studies have shown that continuous dopamine stimulation was helpful in reducing...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1977
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1977.tb16746.x